2FME

Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide

Summary for 2FME

• Entry DOI: 10.2210/pdb2fme/pdb
• Descriptor: Kinesin-like protein KIF11, MAGNESIUM ION, (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE, ... (5 entities in total)
• Functional Keywords: eg5 ksp mg-adp complex inhibitor, cell cycle
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P52732
• Total number of polymer chains: 2
• Total formula weight: 83663.01

Authors

Sheriff, S. (deposition date: 2006-01-09, release date: 2006-04-18, Last modification date: 2024-04-03)

• Primary citation: Tarby, C.M.,Kaltenbach III, R.F.,Huynh, T.,Pudzianowski, A.,Shen, H.,Ortega-Nanos, M.,Sheriff, S.,Newitt, J.A.,McDonnell, P.A.,Burford, N.,Fairchild, C.R.,Vaccaro, W.,Chen, Z.,Borzilleri, R.M.,Naglich, J.,Lombardo, L.J.,Gottardis, M.,Trainor, G.L.,Roussell, D.L.; Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series; Bioorg.Med.Chem.Lett., 16:2095-2100, 2006; PubMed: 16458511; DOI: 10.1016/j.bmcl.2006.01.056

Experimental method

X-RAY DIFFRACTION (2.1 Å)