2FGU

X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.

Summary for 2FGU

Entry DOI	10.2210/pdb2fgu/pdb
Related	2FGV
Descriptor	Protease, PHOSPHATE ION, quinoline-2-carboxylic acid, ... (8 entities in total)
Functional Keywords	hiv protease, drug resistance, enzyme kinetics, sequence conservation, protein structure, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22793.23
Authors	Foulkes, J.E.,Prabu-Jeyabalan, M.,Cooper, D.,Schiffer, C.A. (deposition date: 2005-12-22, release date: 2006-11-07, Last modification date: 2023-08-30)
Primary citation	Foulkes, J.E.,Prabu-Jeyabalan, M.,Cooper, D.,Henderson, G.J.,Harris, J.,Swanstrom, R.,Schiffer, C.A. Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity. J.Virol., 80:6906-6916, 2006 Cited by PubMed: 16809296 DOI: 10.1128/JVI.01900-05 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation