2FDW

Crystal Structure Of Human Microsomal P450 2A6 with the inhibitor (5-(Pyridin-3-yl)furan-2-yl)methanamine bound

Summary for 2FDW

Entry DOI	10.2210/pdb2fdw/pdb
Related	1Z10 1Z11 2FDU 2FDV 2FDY
Descriptor	Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE, ... (4 entities in total)
Functional Keywords	cyp2a6, p450 2a6, p450, monooxygenase, drug metabolizing enzyme, coumarin 7-hydroxylase, nicotine oxidase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	4
Total formula weight	221849.29
Authors	Yano, J.K.,Stout, C.D.,Johnson, E.F. (deposition date: 2005-12-14, release date: 2006-11-28, Last modification date: 2023-08-30)
Primary citation	Yano, J.K.,Denton, T.T.,Cerny, M.A.,Zhang, X.,Johnson, E.F.,Cashman, J.R. Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization. J.Med.Chem., 49:6987-7001, 2006 Cited by PubMed: 17125252 DOI: 10.1021/jm060519r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation