2FB8
Structure of the B-Raf kinase domain bound to SB-590885
Summary for 2FB8
Entry DOI | 10.2210/pdb2fb8/pdb |
Descriptor | B-Raf proto-oncogene serine/threonine-protein kinase, (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME (3 entities in total) |
Functional Keywords | kinase domain, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 2 |
Total formula weight | 64734.83 |
Authors | Lougheed, J.C.,Lee, J.,Chau, D.C.,Stout, T.J. (deposition date: 2005-12-08, release date: 2006-12-12, Last modification date: 2024-02-14) |
Primary citation | King, A.J.,Patrick, D.R.,Batorsky, R.S.,Ho, M.L.,Do, H.T.,Zhang, S.Y.,Kumar, R.,Rusnak, D.W.,Takle, A.K.,Wilson, D.M.,Hugger, E.,Wang, L.,Karreth, F.,Lougheed, J.C.,Lee, J.,Chau, D.,Stout, T.J.,May, E.W.,Rominger, C.M.,Schaber, M.D.,Luo, L.,Lakdawala, A.S.,Adams, J.L.,Contractor, R.G.,Smalley, K.S.,Herlyn, M.,Morrissey, M.M.,Tuveson, D.A.,Huang, P.S. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res., 66:11100-11105, 2006 Cited by PubMed: 17145850DOI: 10.1158/0008-5472.CAN-06-2554 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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