2F6F
The structure of the S295F mutant of human PTP1B
Summary for 2F6F
Entry DOI | 10.2210/pdb2f6f/pdb |
Descriptor | Tyrosine-protein phosphatase, non-receptor type 1, CHLORIDE ION, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | phosphatase, ligand binding, mutations, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35396.15 |
Authors | Montalibet, J.,Skorey, K.,McKay, D.,Scapin, G.,Asante-Appiah, E.,Kennedy, B.P. (deposition date: 2005-11-29, release date: 2005-12-06, Last modification date: 2023-08-23) |
Primary citation | Montalibet, J.,Skorey, K.,McKay, D.,Scapin, G.,Asante-Appiah, E.,Kennedy, B.P. Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding. J.Biol.Chem., 281:5258-5266, 2006 Cited by PubMed: 16332678DOI: 10.1074/jbc.M511546200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report