2E8A

Crystal structure of the human Hsp70 ATPase domain in complex with AMP-PNP

Summary for 2E8A

Entry DOI	10.2210/pdb2e8a/pdb
Related	2E88
Descriptor	Heat shock 70kDa protein 1A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	hydrolase, anp, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	43624.21
Authors	Shida, M.,Ishii, R.,Takagi, T.,Kishishita, S.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-01-19, release date: 2008-01-22, Last modification date: 2023-10-25)
Primary citation	Shida, M.,Arakawa, A.,Ishii, R.,Kishishita, S.,Takagi, T.,Kukimoto-Niino, M.,Sugano, S.,Tanaka, A.,Shirouzu, M.,Yokoyama, S. Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66:223-232, 2010 Cited by PubMed: 20179333 DOI: 10.1107/S0907444909053979 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation