2DDF
Crystal structure of TACE in complex with TAPI-2
Summary for 2DDF
Entry DOI | 10.2210/pdb2ddf/pdb |
Related | 1BKC |
Related PRD ID | PRD_000919 |
Descriptor | ADAM 17, ZINC ION, CALCIUM ION, ... (8 entities in total) |
Functional Keywords | tace adam17 zn-endopeptidase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 59522.52 |
Authors | Orth, P. (deposition date: 2006-01-28, release date: 2006-03-14, Last modification date: 2023-08-23) |
Primary citation | Ingram, R.N.,Orth, P.,Strickland, C.L.,Le, H.V.,Madison, V.,Beyer, B.M. Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies. Protein Eng.Des.Sel., 19:155-161, 2006 Cited by PubMed: 16459338DOI: 10.1093/protein/gzj014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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