2BMC
Aurora-2 T287D T288D complexed with PHA-680632
Summary for 2BMC
Entry DOI | 10.2210/pdb2bmc/pdb |
Related | 1MQ4 1MUO 1OL5 1OL6 1OL7 |
Descriptor | SERINE THREONINE-PROTEIN KINASE 6, (3E)-N-(2,6-DIETHYLPHENYL)-3-{[4-(4-METHYLPIPERAZIN-1-YL)BENZOYL]IMINO}PYRROLO[3,4-C]PYRAZOLE-5(3H)-CARBOXAMIDE (3 entities in total) |
Functional Keywords | cell cycle, transferase, serine/threonine-protein kinase, atp-binding, phosphorylation |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 6 |
Total formula weight | 214816.53 |
Authors | Cameron, A.D.,Izzo, G.,Sagliano, A.,Rusconi, L.,Storici, P.,Fancelli, D.,Berta, D.,Bindi, S.,Catana, C.,Forte, B.,Giordano, P.,Mantegani, S.,Meroni, M.,Moll, J.,Pittala, V.,Severino, D.,Tonani, R.,Varasi, M.,Vulpetti, A.,Vianello, P. (deposition date: 2005-03-11, release date: 2005-03-17, Last modification date: 2024-05-01) |
Primary citation | Fancelli, D.,Berta, D.,Bindi, S.,Cameron, A.,Cappella, P.,Carpinelli, P.,Catana, C.,Forte, B.,Giordano, P.,Giorgini, M.L.,Mantegani, S.,Marsiglio, A.,Meroni, M.,Moll, J.,Pittala, V.,Roletto, F.,Severino, D.,Soncini, C.,Storici, P.,Tonani, R.,Varasi, M.,Vulpetti, A.,Vianello, P. Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition. J.Med.Chem., 48:3080-, 2005 Cited by PubMed: 15828847DOI: 10.1021/JM049076M PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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