2AUH

Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase

Summary for 2AUH

Entry DOI	10.2210/pdb2auh/pdb
Descriptor	Insulin receptor, Growth factor receptor-bound protein 14, CALCIUM ION (3 entities in total)
Functional Keywords	tyrosine kinase, bps region, transferase-signaling protein complex, transferase/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P06213 Cytoplasm: Q14449
Total number of polymer chains	2
Total formula weight	41439.91
Authors	Depetris, R.S.,Hu, J.,Gimpelevich, I.,Holt, L.J.,Daly, R.J.,Hubbard, S.R. (deposition date: 2005-08-27, release date: 2005-11-01, Last modification date: 2023-11-15)
Primary citation	Depetris, R.S.,Hu, J.,Gimpelevich, I.,Holt, L.J.,Daly, R.J.,Hubbard, S.R. Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20:325-333, 2005 Cited by PubMed: 16246733 DOI: 10.1016/j.molcel.2005.09.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation