2ANM

Ternary complex of an orally active thrombin inhibitor with human thrombin and a c-terminal hirudin derived exo-sit inhibitor

Summary for 2ANM

• Entry DOI: 10.2210/pdb2anm/pdb
• Descriptor: thrombin, 2-((R)-1-((S)-2-(N-(6-CARBAMIMIDOYLPYRIDIN-3-YL)METHYLCARBAMOYL)-2H-PYRROL-1(5H)-YL)-3-CYCLOHEXYL-1-OXOPROPAN-2-YLAMINO)ACETIC ACID, ... (4 entities in total)
• Functional Keywords: blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 2
• Total formula weight: 34147.13

Authors

Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (deposition date: 2005-08-11, release date: 2006-06-13, Last modification date: 2017-10-11)

• Primary citation: Lange, U.E.W.,Baucke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W.; Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety; Bioorg.Med.Chem.Lett., 16:2648-2653, 2006; PubMed: 16460939; DOI: 10.1016/j.bmcl.2006.01.046

Experimental method

X-RAY DIFFRACTION (2.4 Å)