2AEW

A model for growth hormone receptor activation based on subunit rotation within a receptor dimer

Summary for 2AEW

Entry DOI	10.2210/pdb2aew/pdb
Descriptor	Growth hormone receptor (2 entities in total)
Functional Keywords	hormone/growth factor, hormone-growth factor complex
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912
Total number of polymer chains	2
Total formula weight	47901.80
Authors	Adams, J.J.,McKinstry, W.J.,Parker, M.W.,Waters, M.J. (deposition date: 2005-07-24, release date: 2005-11-01, Last modification date: 2023-10-25)
Primary citation	Brown, R.J.,Adams, J.J.,Pelekanos, R.A.,Wan, Y.,McKinstry, W.J.,Palethorpe, K.,Seeber, R.M.,Monks, T.A.,Eidne, K.A.,Parker, M.W.,Waters, M.J. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat.Struct.Mol.Biol., 12:814-821, 2005 Cited by PubMed: 16116438 DOI: 10.1038/nsmb977 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation