296D
SEQUENCE-DEPENDENT EFFECTS IN DRUG-DNA INTERACTION: THE CRYSTAL STRUCTURE OF HOECHST 33258 BOUND TO THE D(CGCAAATTTGCG)2 DUPLEX
Summary for 296D
Entry DOI | 10.2210/pdb296d/pdb |
Descriptor | DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE (3 entities in total) |
Functional Keywords | b-dna, double helix, complexed with drug, dna |
Total number of polymer chains | 2 |
Total formula weight | 7749.31 |
Authors | Spink, N.,Brown, D.G.,Skelly, J.V.,Neidle, S. (deposition date: 1994-07-21, release date: 1996-12-04, Last modification date: 2024-02-14) |
Primary citation | Spink, N.,Brown, D.G.,Skelly, J.V.,Neidle, S. Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex. Nucleic Acids Res., 22:1607-1612, 1994 Cited by PubMed: 7515488DOI: 10.1093/nar/22.9.1607 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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