1ZYJ
Human P38 MAP Kinase in Complex with Inhibitor 1a
Summary for 1ZYJ
Entry DOI | 10.2210/pdb1zyj/pdb |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41939.91 |
Authors | Karpusas, M.,Michelotti, E.L.,Springman, E.B. (deposition date: 2005-06-10, release date: 2005-11-08, Last modification date: 2023-08-23) |
Primary citation | Michelotti, E.L.,Moffett, K.K.,Nguyen, D.,Kelly, M.J.,Shetty, R.,Chai, X.,Northrop, K.,Namboodiri, V.,Campbell, B.,Flynn, G.A.,Fujimoto, T.,Hollinger, F.P.,Bukhtiyarova, M.,Springman, E.B.,Karpusas, M. Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg.Med.Chem.Lett., 15:5274-5279, 2005 Cited by PubMed: 16169718DOI: 10.1016/j.bmcl.2005.08.038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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