1ZY8

The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.

Summary for 1ZY8

• Entry DOI: 10.2210/pdb1zy8/pdb
• Related: 1ni4
• Descriptor: Dihydrolipoyl dehydrogenase, mitochondrial, Pyruvate dehydrogenase protein X component, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: human, dihydrolipoamide dehydrogenase, e3, dihydrolipoyl dehydrogenase, dihydrolipoamide dehydrogenase binding protein, e3-binding protein, pyruvate dehydrogenase complex, alpha-keto acid complex, flavin adenine dinucleotide cofactor, oxidoreductase
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix: P09622 O00330
• Total number of polymer chains: 15
• Total formula weight: 632469.59

Authors

Ciszak, E.M.,Makal, A.,Hong, Y.S.,Vettaikkorumakankauv, A.K.,Korotchkina, L.G.,Patel, M.S. (deposition date: 2005-06-09, release date: 2005-11-15, Last modification date: 2023-08-23)

• Primary citation: Ciszak, E.M.,Makal, A.,Hong, Y.S.,Vettaikkorumakankauv, A.K.,Korotchkina, L.G.,Patel, M.S.; How Dihydrolipoamide Dehydrogenase-binding Protein Binds Dihydrolipoamide Dehydrogenase in the Human Pyruvate Dehydrogenase Complex.; J.Biol.Chem., 281:648-655, 2006; PubMed: 16263718; DOI: 10.1074/jbc.M507850200

Experimental method

X-RAY DIFFRACTION (2.59 Å)