1ZSL
Factor XI complexed with a pyrimidinone inhibitor
Summary for 1ZSL
Entry DOI | 10.2210/pdb1zsl/pdb |
Related | 1ZHR |
Descriptor | Coagulation factor XI, 2-(2-(3,4-DICHLOROPHENYL)-5-(ISOPROPYLAMINO)-6-OXOPYRIMIDIN-1(6H)-YL)-N-((S)-1-OXO-1-(THIAZOL-2-YL)-5-GUANIDINOPENTAN-2-YL)ACETAMIDE (3 entities in total) |
Functional Keywords | serine protease, coagulation, covalent complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27377.90 |
Authors | Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.,Strickler, J.,Abdel-Meguid, S. (deposition date: 2005-05-24, release date: 2006-05-09, Last modification date: 2023-08-23) |
Primary citation | Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.,Strickler, J.,Abdel-Meguid, S. Pyrimidinone Inhibitors of a Thrombolytic Protease To be Published, |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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