1ZMN
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenyl)guanidine
Summary for 1ZMN
Entry DOI | 10.2210/pdb1zmn/pdb |
Related | 1ZMJ 1ZML |
Descriptor | Coagulation factor XI, SULFATE ION, (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE, ... (4 entities in total) |
Functional Keywords | fxi, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27275.60 |
Authors | Lazarova, T.I.,Jin, L.,Rynkiewicz, M.J.,Gorga, J.C.,Bibbins, F.,Meyers, H.V.,Babine, R.E.,Strickler, J.E. (deposition date: 2005-05-10, release date: 2006-05-09, Last modification date: 2023-08-23) |
Primary citation | Lazarova, T.I.,Jin, L.,Rynkiewicz, M.,Gorga, J.C.,Bibbins, F.,Meyers, H.V.,Babine, R.,Strickler, J. Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa. Bioorg.Med.Chem.Lett., 16:5022-5027, 2006 Cited by PubMed: 16876411DOI: 10.1016/j.bmcl.2006.07.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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