1ZLR
Factor XI catalytic domain complexed with 2-guanidino-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl nicotinate
Summary for 1ZLR
Entry DOI | 10.2210/pdb1zlr/pdb |
Related | 1ZHR |
Descriptor | Coagulation factor XI, SULFATE ION, (1R)-2-{[AMINO(IMINO)METHYL]AMINO}-1-{4-[(4R)-4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL]PHENYL}ETHYL NICOTINATE, ... (5 entities in total) |
Functional Keywords | serine protease, boron, covalent inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27417.71 |
Authors | Lazarova, T.I.,Jin, L.,Rynkiewicz, M.,Gorga, J.C.,Bibbins, F.,Meyers, H.V.,Babine, R.,Strickler, J. (deposition date: 2005-05-09, release date: 2006-05-09, Last modification date: 2023-08-23) |
Primary citation | Lazarova, T.I.,Jin, L.,Rynkiewicz, M.,Gorga, J.C.,Bibbins, F.,Meyers, H.V.,Babine, R.,Strickler, J. Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa. Bioorg.Med.Chem.Lett., 16:5022-5027, 2006 Cited by PubMed: 16876411DOI: 10.1016/j.bmcl.2006.07.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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