1YQJ
Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor
Summary for 1YQJ
Entry DOI | 10.2210/pdb1yqj/pdb |
Descriptor | Mitogen-activated protein kinase 14, SULFATE ION, 6((S)-3-BENZYLPIPERAZIN-1-YL)-3-(NAPHTHALEN-2-YL)-4-(PYRIDIN-4-YL)PYRAZINE, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42552.57 |
Authors | Tamayo, N.,Liao, H.,Goldberg, M.,Syed, R.,Li, V.,Powers, D.,Tudor, Y.,Yu, V.,Wong, M.L.,Henkle, B.,Middelton, S.,Harvey, T.,Jang, G.,Hungate, R.,Dominguez, C. (deposition date: 2005-02-01, release date: 2005-04-26, Last modification date: 2023-08-23) |
Primary citation | Tamayo, N.,Liao, L.,Goldberg, M.,Powers, D.,Tudor, Y.Y.,Yu, V.,Wong, L.M.,Henkle, B.,Middleton, S.,Syed, R.,Harvey, T.,Jang, G.,Hungate, R.,Dominguez, C. Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 15:2409-2413, 2005 Cited by PubMed: 15837335DOI: 10.1016/j.bmcl.2005.02.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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