1YGC
Short Factor VIIa with a small molecule inhibitor
Summary for 1YGC
Entry DOI | 10.2210/pdb1ygc/pdb |
Related | 1DAN 1jbu 1KLI 1KLJ |
Descriptor | Coagulation factor VII, CALCIUM ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | inverted oxy-anion hole, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 36273.19 |
Authors | Olivero, A.G.,Eigenbrot, C.,Goldsmith, R.,Robarge, K.,Artis, D.R.,Flygare, J.,Rawson, T.,Refino, C.,Bunting, S.,Kirchhofer, D. (deposition date: 2005-01-04, release date: 2005-01-18, Last modification date: 2011-07-13) |
Primary citation | Olivero, A.G.,Eigenbrot, C.,Goldsmith, R.,Robarge, K.,Artis, D.R.,Flygare, J.,Rawson, T.,Sutherlin, D.P.,Kadkhodayan, S.,Beresini, M.,Elliott, L.O.,DeGuzman, G.G.,Banner, D.W.,Ultsch, M.,Marzec, U.,Hanson, S.R.,Refino, C.,Bunting, S.,Kirchhofer, D. A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo. J.Biol.Chem., 280:9160-9169, 2005 Cited by PubMed: 15632123DOI: 10.1074/jbc.M409068200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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