1WM0

PPARgamma in complex with a 2-BABA compound

Summary for 1WM0

Entry DOI	10.2210/pdb1wm0/pdb
Descriptor	Peroxisome proliferator activated receptor gamma, 14-mer from Nuclear receptor coactivator 2, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID (3 entities in total)
Functional Keywords	three-layer helical domain, transcription-signaling protein complex, transcription/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein (Potential): Q96J12 Nucleus: Q61026
Total number of polymer chains	2
Total formula weight	35382.64
Authors	Ostberg, T.,Svensson, S.,Selen, G.,Uppenberg, J.,Thor, M.,Sundbom, M.,Sydow-Backman, M.,Gustavsson, A.L.,Jendeberg, L. (deposition date: 2004-07-01, release date: 2004-09-07, Last modification date: 2024-03-13)
Primary citation	Ostberg, T.,Svensson, S.,Selen, G.,Uppenberg, J.,Thor, M.,Sundbom, M.,Sydow-Backman, M.,Gustavsson, A.L.,Jendeberg, L. A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects J.Biol.Chem., 279:41124-41130, 2004 Cited by PubMed: 15258145 DOI: 10.1074/jbc.M401552200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation