1W0C

Inhibition of Leishmania major pteridine reductase (PTR1) by 2,4,6-triaminoquinazoline; structure of the NADP ternary complex.

Summary for 1W0C

• Entry DOI: 10.2210/pdb1w0c/pdb
• Related: 1E7W 1E92
• Descriptor: PTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4,6-TRIAMINOQUINAZOLINE, ... (4 entities in total)
• Functional Keywords: oxidoreductase, enzyme inhibitor, pterin, short-chain reductase, leishmania, methotrexate, trypanosoma, nadp, methotrexate resistance
• Biological source: LEISHMANIA MAJOR
• Total number of polymer chains: 8
• Total formula weight: 268699.73

Authors

Mcluskey, K.,Gibellini, F.,Carvalho, P.,Avery, M.,Hunter, W. (deposition date: 2004-06-02, release date: 2004-09-30, Last modification date: 2023-12-13)

• Primary citation: Mcluskey, K.,Gibellini, F.,Carvalho, P.,Avery, M.,Hunter, W.; Inhibition of Leishmania Major Pteridine Reductase by 2,4,6-Triaminoquinazoline: Structure of the Nadph Ternary Complex; Acta Crystallogr.,Sect.D, 60:1780-, 2004; PubMed: 15388924; DOI: 10.1107/S0907444904018955

Experimental method

X-RAY DIFFRACTION (2.6 Å)