1VJY
Crystal Structure of a Naphthyridine Inhibitor of Human TGF-beta Type I Receptor
Summary for 1VJY
Entry DOI | 10.2210/pdb1vjy/pdb |
Descriptor | TGF-beta receptor type I, 2-[5-(6-METHYLPYRIDIN-2-YL)-2,3-DIHYDRO-1H-PYRAZOL-4-YL]-1,5-NAPHTHYRIDINE (3 entities in total) |
Functional Keywords | transferase, protein kinase, inhibitor complex |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P36897 |
Total number of polymer chains | 1 |
Total formula weight | 35013.33 |
Authors | Gellibert, F.,Woolven, J.,Fouchet, M.-H.,Mathews, N.,Goodland, H.,Lovegrove, V.,Laroze, A.,Nguyen, V.-L.,Sautet, S.,Wang, R.,Janson, C.,Smith, W.,Krysa, G.,Boullay, V.,de Gouville, A.-C.,Huet, S.,Hartley, D. (deposition date: 2004-04-07, release date: 2004-08-31, Last modification date: 2023-12-27) |
Primary citation | Gellibert, F.,Woolven, J.,Fouchet, M.-H.,Mathews, N.,Goodland, H.,Lovegrove, V.,Laroze, A.,Nguyen, V.-L.,Sautet, S.,Wang, R.,Janson, C.,Smith, W.,Krysa, G.,Boullay, V.,De Gouville, A.-C.,Huet, S.,Hartley, D. Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-beta Type I Receptor Inhibitors. J.Med.Chem., 47:4494-4506, 2004 Cited by PubMed: 15317461DOI: 10.1021/jm0400247 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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