1UTS
Designed HIV-1 TAR Binding Ligand
Summary for 1UTS
Entry DOI | 10.2210/pdb1uts/pdb |
Related | 1UUD 1UUI |
Descriptor | RNA (5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3'), N-[2-(3-AMINOPROPOXY)-5-(1H-INDOL-5-YL)BENZYL]-N-(2-PIPERAZIN-1-YLETHYL)AMINE (2 entities in total) |
Functional Keywords | hiv-1, tar rna, drug design, antiviral, ligand binding, conformational change |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS 1 (HIV-1) |
Total number of polymer chains | 1 |
Total formula weight | 9715.11 |
Authors | Davis, B.,Murchie, A.I.H.,Aboul-Ela, F.,Karn, J. (deposition date: 2003-12-10, release date: 2004-02-12, Last modification date: 2024-05-15) |
Primary citation | Murchie, A.I.,Davis, B.,Isel, C.,Afshar, M.,Drysdale, M.J.,Bower, J.,Potter, A.J.,Starkey, I.D.,Swarbrick, T.M.,Mirza, S.,Prescott, C.D.,Vaglio, P.,Aboul-ela, F.,Karn, J. Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA. J.Mol.Biol., 336:625-638, 2004 Cited by PubMed: 15095977DOI: 10.1016/j.jmb.2003.12.028 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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