1U72
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
Summary for 1U72
Entry DOI | 10.2210/pdb1u72/pdb |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total) |
Functional Keywords | wild type humand dhfr, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22549.38 |
Authors | Cody, V. (deposition date: 2004-08-02, release date: 2005-02-01, Last modification date: 2024-02-14) |
Primary citation | Cody, V.,Luft, J.R.,Pangborn, W. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61:147-155, 2005 Cited by PubMed: 15681865DOI: 10.1107/S0907444904030422 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report