1TZN
Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore bound to the VWA domain of CMG2, an anthrax toxin receptor
Summary for 1TZN
Entry DOI | 10.2210/pdb1tzn/pdb |
Related | 1SHT 1TZO |
Descriptor | Protective antigen, Anthrax toxin receptor 2, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | heptamer, toxin receptor-toxin complex, toxin receptor/toxin |
Biological source | Bacillus anthracis str. More |
Cellular location | Secreted, extracellular space: P13423 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P58335 |
Total number of polymer chains | 28 |
Total formula weight | 1161499.70 |
Authors | Lacy, D.B.,Wigelsworth, D.J.,Melnyk, R.A.,Collier, R.J. (deposition date: 2004-07-10, release date: 2004-08-17, Last modification date: 2024-04-03) |
Primary citation | Lacy, D.B.,Wigelsworth, D.J.,Melnyk, R.A.,Harrison, S.C.,Collier, R.J. Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation Proc.Natl.Acad.Sci.USA, 101:13147-13151, 2004 Cited by PubMed: 15326297DOI: 10.1073/pnas.0405405101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.3 Å) |
Structure validation
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