1TWX
Crystal structure of the thrombin mutant D221A/D222K
Summary for 1TWX
Entry DOI | 10.2210/pdb1twx/pdb |
Descriptor | Prothrombin, Hirudin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | thrombin, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 34566.56 |
Authors | Pineda, A.O.,Zhang, E.,Guinto, E.R.,Savvides, S.N.,Tulinsky, A.,Di Cera, E. (deposition date: 2004-07-01, release date: 2005-04-19, Last modification date: 2023-11-15) |
Primary citation | Pineda, A.O.,Zhang, E.,Guinto, E.R.,Savvides, S.N.,Tulinsky, A.,Di Cera, E. Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form Biophys.Chem., 112:253-256, 2004 Cited by PubMed: 15572256DOI: 10.1016/j.bpc.2004.07.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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