1TVK

The binding mode of epothilone A on a,b-tubulin by electron crystallography

Summary for 1TVK

• Entry DOI: 10.2210/pdb1tvk/pdb
• Related: 1JFF 1TUB
• Descriptor: Tubulin alpha chain, Tubulin beta chain, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: epothilone; taxol; ligand interactions, cell cycle, structural protein
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 2
• Total formula weight: 98270.10

Authors

Nettles, J.H.,Li, H.,Cornett, B.,Krahn, J.M.,Snyder, J.P.,Downing, K.H. (deposition date: 2004-06-29, release date: 2004-09-14, Last modification date: 2023-08-23)

• Primary citation: Nettles, J.H.,Li, H.,Cornett, B.,Krahn, J.M.,Snyder, J.P.,Downing, K.H.; The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography; Science, 305:866-869, 2004; PubMed: 15297674; DOI: 10.1126/science.1099190

Experimental method

ELECTRON CRYSTALLOGRAPHY (2.89 Å)