1TSY
THYMIDYLATE SYNTHASE R179K MUTANT
Summary for 1TSY
Entry DOI | 10.2210/pdb1tsy/pdb |
Descriptor | THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (3 entities in total) |
Functional Keywords | transferase, methyltransferase, nucleotide biosynthesis |
Biological source | Lactobacillus casei |
Cellular location | Cytoplasm: P00469 |
Total number of polymer chains | 1 |
Total formula weight | 36910.62 |
Authors | Finer-Moore, J.,Stroud, R.M. (deposition date: 1995-12-05, release date: 1996-03-08, Last modification date: 2024-02-14) |
Primary citation | Finer-Moore, J.S.,Fauman, E.B.,Morse, R.J.,Santi, D.V.,Stroud, R.M. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9:69-75, 1996 Cited by PubMed: 9053905DOI: 10.1093/protein/9.1.69 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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