1TOM
ALPHA-THROMBIN COMPLEXED WITH HIRUGEN
Summary for 1TOM
Entry DOI | 10.2210/pdb1tom/pdb |
Descriptor | ALPHA-THROMBIN, HIRUGEN, METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE, ... (5 entities in total) |
Functional Keywords | hydrolase, serine protease, kringle, disease mutation, complex (hydrolase-inhibitor), hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor |
Biological source | Hirudo medicinalis (medicinal leech) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28507 |
Total number of polymer chains | 3 |
Total formula weight | 35869.90 |
Authors | Chen, Z. (deposition date: 1996-12-06, release date: 1997-03-12, Last modification date: 2024-06-05) |
Primary citation | Lyle, T.A.,Chen, Z.G.,Appleby, S.D.,Freidinger, R.M.,Gardell, S.J.,Lewis, S.D.,Li, Y.,Lyle, E.A.,Lynch, J.J.,Mulichak, A.M.,Ng, A.S.,NaylorOlsen, A.M.,Sanders, W.M. Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor. Bioorg.Med.Chem.Lett., 7:67-72, 1997 Cited by |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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