1TJP

Crystal Structure Of Wild-Type Tryptophan Synthase Complexed With 1-[(2-hydroxylphenyl)amino]3-glycerolphosphate

Summary for 1TJP

Entry DOI	10.2210/pdb1tjp/pdb
Related	1QOP 1TJR
Descriptor	Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 1-[(2-HYDROXYLPHENYL)AMINO]3-GLYCEROLPHOSPHATE, ... (6 entities in total)
Functional Keywords	substrate channeling, transition state analog, enzymatic mechanism, allosteric regulation, lyase
Biological source	Salmonella typhimurium More
Total number of polymer chains	2
Total formula weight	72035.80
Authors	Kulik, V.,Hartmann, E.,Weyand, M.,Frey, M.,Gierl, A.,Niks, D.,Dunn, M.F.,Schlichting, I. (deposition date: 2004-06-07, release date: 2005-12-27, Last modification date: 2011-07-13)
Primary citation	Kulik, V.,Hartmann, E.,Weyand, M.,Frey, M.,Gierl, A.,Niks, D.,Dunn, M.F.,Schlichting, I. On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. J.Mol.Biol., 352:608-620, 2005 Cited by PubMed: 16120446 DOI: 10.1016/j.jmb.2005.07.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation