1THP
STRUCTURE OF HUMAN ALPHA-THROMBIN Y225P MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE
Summary for 1THP
Entry DOI | 10.2210/pdb1thp/pdb |
Related PRD ID | PRD_000020 |
Descriptor | PROTEIN (THROMBIN LIGHT CHAIN), PROTEIN (THROMBIN HEAVY CHAIN), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (4 entities in total) |
Functional Keywords | serine protease, fprck, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 2 |
Total formula weight | 34264.68 |
Authors | Caccia, S.,Futterer, K.,Di Cera, E.,Waksman, G. (deposition date: 1999-01-26, release date: 1999-03-03, Last modification date: 2023-08-23) |
Primary citation | Guinto, E.R.,Caccia, S.,Rose, T.,Futterer, K.,Waksman, G.,Di Cera, E. Unexpected crucial role of residue 225 in serine proteases. Proc.Natl.Acad.Sci.USA, 96:1852-1857, 1999 Cited by PubMed: 10051558DOI: 10.1073/pnas.96.5.1852 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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