1TD7

Interactions of a specific non-steroidal anti-inflammatory drug (NSAID) with group I phospholipase A2 (PLA2): Crystal structure of the complex formed between PLA2 and niflumic acid at 2.5 A resolution

Summary for 1TD7

• Entry DOI: 10.2210/pdb1td7/pdb
• Related: 1MF4
• Descriptor: Phospholipase A2 isoform 3, CALCIUM ION, 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID, ... (4 entities in total)
• Functional Keywords: phospholipase a2, enzyme, inhibitor, hydrolase
• Biological source: Naja sagittifera
• Cellular location: Secreted: P60045
• Total number of polymer chains: 1
• Total formula weight: 13505.89

Authors

Jabeen, T.,Singh, N.,Singh, R.K.,Sharma, S.,Perbandt, M.,Betzel, C.,Singh, T.P. (deposition date: 2004-05-21, release date: 2004-06-08, Last modification date: 2023-10-25)

• Primary citation: Jabeen, T.,Singh, N.,Singh, R.K.,Sharma, S.,Somvanshi, R.K.,Dey, S.,Singh, T.P.; Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution.; Acta Crystallogr.,Sect.D, 61:1579-1586, 2005; PubMed: 16301791; DOI: 10.1107/S0907444905029604

Experimental method

X-RAY DIFFRACTION (2.5 Å)