1TCO
TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
Summary for 1TCO
Entry DOI | 10.2210/pdb1tco/pdb |
Descriptor | SERINE/THREONINE PHOSPHATASE B2, FK506-BINDING PROTEIN, ZINC ION, ... (10 entities in total) |
Functional Keywords | complex (hydrolase-isomerase), immunosuppressant, complex (hydrolase-isomerase) complex, complex (hydrolase/isomerase) |
Biological source | Bos taurus (cattle) More |
Cellular location | Nucleus (By similarity): P48452 Cytoplasm: P62942 |
Total number of polymer chains | 3 |
Total formula weight | 75364.00 |
Authors | Griffith, J.P.,Kim, J.L.,Kim, E.E.,Sintchak, M.D.,Thomson, J.A.,Fitzgibbon, M.J.,Fleming, M.A.,Caron, P.R.,Hsiao, K.,Navia, M.A. (deposition date: 1996-08-21, release date: 1997-02-12, Last modification date: 2024-06-05) |
Primary citation | Griffith, J.P.,Kim, J.L.,Kim, E.E.,Sintchak, M.D.,Thomson, J.A.,Fitzgibbon, M.J.,Fleming, M.A.,Caron, P.R.,Hsiao, K.,Navia, M.A. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell(Cambridge,Mass.), 82:507-522, 1995 Cited by PubMed: 7543369DOI: 10.1016/0092-8674(95)90439-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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