1TBZ
HUMAN THROMBIN WITH ACTIVE SITE N-METHYL-D PHENYLALANYL-N-[5-(AMINOIMINOMETHYL)AMINO]-1-{{BENZOTHIAZOLYL)CARBONYL] BUTYL]-L-PROLINAMIDE TRIFLUROACETATE AND EXOSITE-HIRUGEN
Summary for 1TBZ
Entry DOI | 10.2210/pdb1tbz/pdb |
Related PRD ID | PRD_000621 |
Descriptor | ALPHA-THROMBIN, HIRUGEN, D-phenylalanyl-N-{(1S)-1-[(S)-1,3-benzothiazol-2-yl(hydroxy)methyl]-4-carbamimidamidobutyl}-L-prolinamide, ... (6 entities in total) |
Functional Keywords | complex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P09945 Secreted: P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35994.96 |
Authors | Matthews, J.H.,Krishnan, R.,Costanzo, M.J.,Maryanoff, B.E.,Tulinsky, A. (deposition date: 1998-02-05, release date: 1998-05-27, Last modification date: 2023-08-09) |
Primary citation | Matthews, J.H.,Krishnan, R.,Costanzo, M.J.,Maryanoff, B.E.,Tulinsky, A. Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site. Biophys.J., 71:2830-2839, 1996 Cited by PubMed: 8913620PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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