1TA6
Crystal structure of thrombin in complex with compound 14b
Summary for 1TA6
Entry DOI | 10.2210/pdb1ta6/pdb |
Related | 1SL3 1TA2 |
Descriptor | thrombin, Hirudin, 1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE, ... (4 entities in total) |
Functional Keywords | thrombin inhibitor complex, blood clotting, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 Secreted: P28504 |
Total number of polymer chains | 2 |
Total formula weight | 34935.42 |
Authors | Tucker, T.J.,Brady, S.F.,Lumma, W.C.,Lewis, S.D.,Gardel, S.J.,Naylor-Olsen, A.M.,Yan, Y.,Sisko, J.T.,Stauffer, K.J.,Lucas, B.Y.,Lynch, J.J.,Cook, J.J.,Stranieri, M.T.,Holahan, M.A.,Lyle, E.A.,Baskin, E.P.,Chen, I.-W.,Dancheck, K.B.,Krueger, J.A.,Cooper, C.M.,Vacca, J.P. (deposition date: 2004-05-19, release date: 2004-06-08, Last modification date: 2017-10-11) |
Primary citation | Tucker, T.J.,Brady, S.F.,Lumma, W.C.,Lewis, S.D.,Gardel, S.J.,Naylor-Olsen, A.M.,Yan, Y.,Sisko, J.T.,Stauffer, K.J.,Lucas, B.Y.,Lynch, J.J.,Cook, J.J.,Stranieri, M.T.,Holahan, M.A.,Lyle, E.A.,Baskin, E.P.,Chen, I.-W.,Dancheck, K.B.,Krueger, J.A.,Cooper, C.M.,Vacca, J.P. Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position J.Med.Chem., 41:3210-3219, 1998 Cited by PubMed: 9703466DOI: 10.1021/jm9801713 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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