1SYS

Crystal structure of HLA, B*4403, and peptide EEPTVIKKY

Summary for 1SYS

Entry DOI	10.2210/pdb1sys/pdb
Descriptor	leukocyte antigen (HLA) class I molecule, Beta-2-microglobulin, Sorting nexin 5, ... (4 entities in total)
Functional Keywords	hla, mhc, class i, b44, immune system
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P30481 Secreted: P61769 Early endosome membrane; Peripheral membrane protein; Cytoplasmic side: Q9Y5X3
Total number of polymer chains	3
Total formula weight	44965.97
Authors	Zernich, D.,Purcell, A.W.,Macdonald, W.A.,Kjer-Nielsen, L.,Ely, L.K.,Laham, N.,Crockford, T.,Mifsud, N.A.,Tait, B.D.,Holdsworth, R.,Brooks, A.G.,Bottomley, S.P.,Beddoe, T.,Peh, C.A.,Rossjohn, J.,McCluskey, J. (deposition date: 2004-04-01, release date: 2004-10-19, Last modification date: 2011-07-13)
Primary citation	Zernich, D.,Purcell, A.W.,Macdonald, W.A.,Kjer-Nielsen, L.,Ely, L.K.,Laham, N.,Crockford, T.,Mifsud, N.A.,Bharadwaj, M.,Chang, L.,Tait, B.D.,Holdsworth, R.,Brooks, A.G.,Bottomley, S.P.,Beddoe, T.,Peh, C.A.,Rossjohn, J.,McCluskey, J. Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion J.Exp.Med., 200:13-24, 2004 Cited by PubMed: 15226359 DOI: 10.1084/jem.20031680 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation