1SYK
Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation
Summary for 1SYK
Entry DOI | 10.2210/pdb1syk/pdb |
Related | 1APM 1ATP 1CTP 1J3H |
Descriptor | cAMP-dependent protein kinase, alpha-catalytic subunit (2 entities in total) |
Functional Keywords | e230q mutant; catalytic subunit; camp-dependent protein kinase; apoenzyme conformation; n-terminal a-helix, transferase |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm . Isoform 2: Cell projection, cilium, flagellum : P05132 |
Total number of polymer chains | 2 |
Total formula weight | 81312.66 |
Authors | Wu, J.,Yang, J.,Madhusudan, N.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S. (deposition date: 2004-04-01, release date: 2005-05-17, Last modification date: 2023-08-23) |
Primary citation | Wu, J.,Yang, J.,Kannan, N.,Madhusudan, N.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci., 14:2871-2879, 2005 Cited by PubMed: 16253959DOI: 10.1110/ps.051715205 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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