1SY6
Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment
Summary for 1SY6
Entry DOI | 10.2210/pdb1sy6/pdb |
Descriptor | OKT3 Fab light chain, OKT3 Fab heavy chain, T-cell surface glycoprotein CD3 gamma/epsilon chain (3 entities in total) |
Functional Keywords | cd3 gamma, cd3 epsilon, okt3 fab, signaling protein-antibiotic complex, signaling protein/antibiotic |
Biological source | Mus musculus (house mouse) More |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P07766 |
Total number of polymer chains | 3 |
Total formula weight | 70159.85 |
Authors | Kjer-Nielsen, L.,Dunstone, M.A.,Kostenko, L.,Ely, L.K.,Beddoe, T.,Misfud, N.A.,Purcell, A.W.,Brooks, A.G.,McCluskey, J.,Rossjohn, J. (deposition date: 2004-03-31, release date: 2004-05-25, Last modification date: 2018-04-04) |
Primary citation | Kjer-Nielsen, L.,Dunstone, M.A.,Kostenko, L.,Ely, L.K.,Beddoe, T.,Mifsud, N.A.,Purcell, A.W.,Brooks, A.G.,McCluskey, J.,Rossjohn, J. Crystal structure of the human T cell receptor CD3(epsilon)(gamma) heterodimer complexed to the therapeutic mAb OKT3. Proc.Natl.Acad.Sci.USA, 101:7675-7680, 2004 Cited by PubMed: 15136729DOI: 10.1073/pnas.0402295101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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