1RW8
Crystal Structure of TGF-beta receptor I kinase with ATP site inhibitor
Summary for 1RW8
Entry DOI | 10.2210/pdb1rw8/pdb |
Descriptor | TGF-beta receptor type I, 3-(4-FLUOROPHENYL)-2-(6-METHYLPYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOLE (3 entities in total) |
Functional Keywords | tgf-beta receptor i, protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P36897 |
Total number of polymer chains | 1 |
Total formula weight | 34744.90 |
Authors | Zhang, F.,Sawyer, J.S. (deposition date: 2003-12-16, release date: 2005-02-01, Last modification date: 2023-08-23) |
Primary citation | Sawyer, J.S.,Beight, D.W.,Britt, K.S.,Anderson, B.D.,Campbell, R.M.,Goodson Jr., T.,Herron, D.K.,Li, H.Y.,McMillen, W.T.,Mort, N.,Parsons, S.,Smith, E.C.,Wagner, J.R.,Yan, L.,Zhang, F.,Yingling, J.M. Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. Bioorg.Med.Chem.Lett., 14:3581-3584, 2004 Cited by PubMed: 15177479DOI: 10.1016/j.bmcl.2004.04.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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