1RV6
Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1
Summary for 1RV6
Entry DOI | 10.2210/pdb1rv6/pdb |
Descriptor | placenta growth factor (PlGF), FLT1 protein, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | plgf, vegf family, cystine knot, growth factor, ligand-receptor complex, specificity, hormone-growth factor-receptor complex, hormone/growth factor/receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P49763 Isoform Flt1: Cell membrane; Single-pass type I membrane protein. Isoform sFlt1: Secreted: P17948 |
Total number of polymer chains | 4 |
Total formula weight | 46403.45 |
Authors | Christinger, H.W.,Fuh, G.,de Vos, A.M.,Wiesmann, C. (deposition date: 2003-12-12, release date: 2004-01-20, Last modification date: 2023-08-23) |
Primary citation | Christinger, H.W.,Fuh, G.,de Vos, A.M.,Wiesmann, C. The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1. J.Biol.Chem., 279:10382-10388, 2004 Cited by PubMed: 14684734DOI: 10.1074/jbc.M313237200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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