1ROS

Crystal structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid

Summary for 1ROS

Entry DOI	10.2210/pdb1ros/pdb
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	macrophage metalloelastase, non-zinc chelator, mmp-12, mmp12 inhibitor, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains	2
Total formula weight	37647.43
Authors	Morales, R.,Perrier, S.,Florent, J.M.,Beltra, J.,Dufour, S.,De Mendez, I.,Manceau, P.,Tertre, A.,Moreau, F.,Compere, D.,Dublanchet, A.C.,O'Gara, M. (deposition date: 2003-12-02, release date: 2004-12-07, Last modification date: 2023-08-23)
Primary citation	Morales, R.,Perrier, S.,Florent, J.M.,Beltra, J.,Dufour, S.,De Mendez, I.,Manceau, P.,Tertre, A.,Moreau, F.,Compere, D.,Dublanchet, A.C.,O'Gara, M. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J.Mol.Biol., 341:1063-1076, 2004 Cited by PubMed: 15289103 DOI: 10.1016/j.jmb.2004.06.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation