1RCJ
Crystal structure of E166A mutant of SHV-1 beta-lactamase with the trans-enamine intermediate of tazobactam
Summary for 1RCJ
Entry DOI | 10.2210/pdb1rcj/pdb |
Related | 1G56 1n9b |
Descriptor | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, TAZOBACTAM TRANS-ENAMINE INTERMEDIATE, ... (4 entities in total) |
Functional Keywords | beta-lactamase, beta-lactam hydrolase, penicillinase, detergent binding, inhibitor design, covalent intermediate, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 30168.49 |
Authors | Padayatti, P.S.,Helfand, M.S.,Totir, M.A.,Carey, M.P.,Hujer, A.M.,Carey, P.R.,Bonomo, R.A.,van den Akker, F. (deposition date: 2003-11-04, release date: 2004-02-17, Last modification date: 2023-08-23) |
Primary citation | Padayatti, P.S.,Helfand, M.S.,Totir, M.A.,Carey, M.P.,Hujer, A.M.,Carey, P.R.,Bonomo, R.A.,Van Den Akker, F. Tazobactam Forms a Stoichiometric trans-Enamine Intermediate in the E166A Variant of SHV-1 beta-Lactamase: 1.63 A Crystal Structure Biochemistry, 43:843-848, 2004 Cited by PubMed: 14744126PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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