1R5K
Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638
Summary for 1R5K
Entry DOI | 10.2210/pdb1r5k/pdb |
Descriptor | Estrogen receptor, (2E)-3-{4-[(1E)-1,2-DIPHENYLBUT-1-ENYL]PHENYL}ACRYLIC ACID (3 entities in total) |
Functional Keywords | alpha helix, helical sandwich, dna binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 |
Total number of polymer chains | 3 |
Total formula weight | 90613.97 |
Authors | Wu, Y.-L.,Yang, X.,Ren, Z.,McDonnell, D.P.,Norris, J.D.,Willson, T.M.,Greene, G.L. (deposition date: 2003-10-10, release date: 2004-11-23, Last modification date: 2023-08-23) |
Primary citation | Wu, Y.L.,Yang, X.,Ren, Z.,McDonnell, D.P.,Norris, J.D.,Willson, T.M.,Greene, G.L. Structural basis for an unexpected mode of SERM-mediated ER antagonism. Mol.Cell, 18:413-424, 2005 Cited by PubMed: 15893725DOI: 10.1016/j.molcel.2005.04.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report