1QVN
Structure of SP4160 Bound to IL-2 V69A
Summary for 1QVN
Entry DOI | 10.2210/pdb1qvn/pdb |
Descriptor | Interleukin-2, ZINC ION, 2-GUANIDINO-4-METHYL-PENTANOIC ACID [2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE (3 entities in total) |
Functional Keywords | il-2 small molecule hot spot, cytokine |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P60568 |
Total number of polymer chains | 4 |
Total formula weight | 64231.50 |
Authors | Thanos, C.D.,Delano, W.L.,Wells, J.A. (deposition date: 2003-08-28, release date: 2005-04-05, Last modification date: 2021-10-27) |
Primary citation | Thanos, C.D.,DeLano, W.L.,Wells, J.A. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc.Natl.Acad.Sci.USA, 103:15422-15427, 2006 Cited by PubMed: 17032757DOI: 10.1073/pnas.0607058103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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