1QR1
POOR BINDING OF A HER-2/NEU EPITOPE (GP2) TO HLA-A2.1 IS DUE TO A LACK OF INTERACTIONS IN THE CENTER OF THE PEPTIDE
Summary for 1QR1
Entry DOI | 10.2210/pdb1qr1/pdb |
Related | 1hhg 1hhh 1hhi 1hhj 1hhk |
Descriptor | HLA-A2.1 HEAVY CHAIN, BETA-2 MICROGLOBULIN, GP2 PEPTIDE, ... (4 entities in total) |
Functional Keywords | peptide-binding superdomain, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted . Note=(Microbial infection) In the presence of M: P61769 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 |
Total number of polymer chains | 6 |
Total formula weight | 89235.35 |
Authors | Kuhns, J.J.,Batalia, M.A.,Yan, S.,Collins, E.J. (deposition date: 1999-06-17, release date: 2000-01-01, Last modification date: 2021-11-03) |
Primary citation | Kuhns, J.J.,Batalia, M.A.,Yan, S.,Collins, E.J. Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide. J.Biol.Chem., 274:36422-36427, 1999 Cited by PubMed: 10593938DOI: 10.1074/jbc.274.51.36422 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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