1QBV
CRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE-MIMETIC INHIBITOR
Summary for 1QBV
Entry DOI | 10.2210/pdb1qbv/pdb |
Descriptor | THROMBIN (LIGHT CHAIN), THROMBIN (HEAVY CHAIN), Hirudin, ... (5 entities in total) |
Functional Keywords | thrombin, inhibitor, 3dp, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28504 |
Total number of polymer chains | 3 |
Total formula weight | 35749.75 |
Authors | Bone, R.,Lu, T.,Illig, C.R.,Soll, R.M.,Spurlino, J.C. (deposition date: 1999-04-27, release date: 1999-10-27, Last modification date: 2017-10-04) |
Primary citation | Bone, R.,Lu, T.,Illig, C.R.,Soll, R.M.,Spurlino, J.C. Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes. J.Med.Chem., 41:2068-2075, 1998 Cited by PubMed: 9622548DOI: 10.1021/jm970796l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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