1Q5D

Epothilone B-bound Cytochrome P450epoK

Summary for 1Q5D

• Entry DOI: 10.2210/pdb1q5d/pdb
• Related: 1PKF 1Q5E
• Descriptor: P450 epoxidase, PROTOPORPHYRIN IX CONTAINING FE, 7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE, ... (4 entities in total)
• Functional Keywords: cytochrome p450, epothilone, oxydoreductase, heme-enzyme, oxidoreductase
• Biological source: Sorangium cellulosum
• Total number of polymer chains: 1
• Total formula weight: 47933.49

Authors

Nagano, S.,Li, H.,Shimizu, H.,Nishida, C.,Ogura, H.,Ortiz de Montellano, P.R.,Poulos, T.L. (deposition date: 2003-08-06, release date: 2003-10-28, Last modification date: 2024-04-03)

• Primary citation: Nagano, S.,Li, H.,Shimizu, H.,Nishida, C.,Ogura, H.,Ortiz de Montellano, P.R.,Poulos, T.L.; Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK; J.Biol.Chem., 278:44886-44893, 2003; PubMed: 12933799; DOI: 10.1074/jbc.M308115200

Experimental method

X-RAY DIFFRACTION (1.93 Å)