1PZK

Cholera Toxin B-Pentamer Complexed With N-Acyl Phenyl Galactoside 9h

Summary for 1PZK

• Entry DOI: 10.2210/pdb1pzk/pdb
• Related: 1PZI 1PZJ
• Descriptor: Cholera Toxin B Subunit, N-{3-[4-(3-AMINO-PROPYL)-PIPERAZIN-1-YL]-PROPYL}-3-(2-THIOPHEN-2-YL-ACETYLAMINO)-5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY)-BENZAMIDE (3 entities in total)
• Functional Keywords: pentamer, monovalent, toxin, inhibitor, cholera
• Biological source: Vibrio cholerae
• Total number of polymer chains: 5
• Total formula weight: 61225.06

Authors

Mitchell, D.D.,Pickens, J.C.,Korotkov, K.,Fan, E.,Hol, W.G.J. (deposition date: 2003-07-11, release date: 2004-03-09, Last modification date: 2023-08-16)

• Primary citation: Mitchell, D.D.,Pickens, J.C.,Korotkov, K.,Fan, E.,Hol, W.G.J.; 3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies; Bioorg.Med.Chem., 12:907-920, 2004; PubMed: 14980603; DOI: 10.1016/j.bmc.2003.12.019

Experimental method

X-RAY DIFFRACTION (1.35 Å)