1PTW
The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis
Summary for 1PTW
Entry DOI | 10.2210/pdb1ptw/pdb |
Descriptor | cAMP-specific phosphodiesterase PDE4D2, ZINC ION, ADENOSINE MONOPHOSPHATE, ... (4 entities in total) |
Functional Keywords | catalytic mechanism, camp hydrolysis crystal structure, binuclear catalysis, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q08499 |
Total number of polymer chains | 4 |
Total formula weight | 167491.25 |
Authors | Huai, Q.,Colicelli, J.,Ke, H. (deposition date: 2003-06-23, release date: 2003-11-11, Last modification date: 2024-02-14) |
Primary citation | Huai, Q.,Colicelli, J.,Ke, H. The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis Biochemistry, 42:13220-13226, 2003 Cited by PubMed: 14609333DOI: 10.1021/bi034653e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report