1PCF

HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

Summary for 1PCF

• Entry DOI: 10.2210/pdb1pcf/pdb
• Descriptor: TRANSCRIPTIONAL COACTIVATOR PC4 (2 entities in total)
• Functional Keywords: transcription, transcriptional cofactor, transcriptional co-activator, ssdna binding, nuclear protein
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P53999
• Total number of polymer chains: 8
• Total formula weight: 62272.19

Authors

Brandsen, J.,Gros, P. (deposition date: 1997-09-09, release date: 1998-03-18, Last modification date: 2024-02-14)

Primary citation

Brandsen, J.,Werten, S.,van der Vliet, P.C.,Meisterernst, M.,Kroon, J.,Gros, P.
C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.
Nat.Struct.Biol., 4:900-903, 1997

PubMed Abstract: The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.

PubMed: 9360603
DOI: 10.1038/nsb1197-900

Experimental method

X-RAY DIFFRACTION (1.74 Å)